Document Details

Document Type : Article In Journal 
Document Title :
Laryngopharyngeal reflux with sore throat: an ultrastructural study of oropharyngeal epithelium.
Laryngopharyngeal reflux with sore throat: an ultrastructural study of oropharyngeal epithelium.
 
Document Language : English 
Abstract : OBJECTIVES: We performed an electron microscopic ultrastructural study of oropharyngeal epithelium in patients with laryngopharyngeal reflux (LPR) and sore throat to evaluate whether dilatation of intercellular spaces could be traced at this level. METHODS: The study included 20 patients with LPR and sore throat and 5 control subjects. The patients were subjected to upper gastrointestinal tract endoscopy and flexible pharyngolaryngoscopy. Oropharyngeal biopsy specimens were taken from the patients and controls for ultrastructural study by transmission electron microscopy. RESULTS: The entire group of patients with LPR showed dilatation of intercellular spaces essentially at the squamous basal and suprabasal levels in their oropharyngeal biopsy specimens, whereas none of the control subjects showed such a morphological marker. CONCLUSIONS: Dilatation of intercellular spaces as a morphological marker can be traced in patients with LPR and sore throat at the level of the oropharynx. This contributes to a better understanding of the pathophysiology of LPR. If this finding is confirmed in a large series, it will represent a cost-effective, relatively noninvasive method for diagnosis of LPR. 
ISSN : 19548386 
Journal Name : Ann Otol Rhinol Laryngol. 
Volume : 118 
Issue Number : 5 
Publishing Year : 2009 AH
2009 AD 
Article Type : Article 
Added Date : Sunday, March 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سامح أمينAmin, Sameh ResearcherDoctorate 
خالد عبد المجيدAbdel Maged, Khalid ResearcherDoctorate 
أشرف نصرNaser, Ashraf ResearcherDoctorate 
حمدى علىAli, BH ResearcherDoctorate 

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